What has been identified as a negative prognostic factor in canine osteosarcoma?

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Multiple Choice

What has been identified as a negative prognostic factor in canine osteosarcoma?

Explanation:
Elevated serum alkaline phosphatase reflects increased osteoblastic activity and bone turnover driven by the tumor, indicating more aggressive disease and a higher risk of metastasis in canine osteosarcoma. This association with shorter survival after treatment makes elevated ALP a negative prognostic factor. In contrast, low calcium or normal ALP don’t carry that same prognostic implication, and age is not consistently linked to worse outcomes in this disease.

Elevated serum alkaline phosphatase reflects increased osteoblastic activity and bone turnover driven by the tumor, indicating more aggressive disease and a higher risk of metastasis in canine osteosarcoma. This association with shorter survival after treatment makes elevated ALP a negative prognostic factor. In contrast, low calcium or normal ALP don’t carry that same prognostic implication, and age is not consistently linked to worse outcomes in this disease.

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